Implications for Human Leukocyte Antigen Antibodies After Lung Transplantation
نویسندگان
چکیده
منابع مشابه
Anti-human leukocyte antigen antibodies and preemptive antibody-directed therapy after lung transplantation.
BACKGROUND Because the development of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) after lung transplantation has been associated with acute and chronic rejection, we implemented a clinical protocol to screen all transplant recipients for DSA and preemptively treat those who developed DSA with rituximab and intravenous immune globulin (IVIG), or IVIG alone. METHODS We co...
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DOI:10.1097/MOT.0000000000000107 Human leukocyte antigen (HLA) antibodies represent important risk factors for transplant rejection and failure. They are now being recognized as specific for epitopes which can be defined structurally with amino acid differences between HLA alleles. Donor-recipient compatibility should, therefore, be assessed at the epitope rather than the antigen level. HLAMatc...
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Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
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The presence of donor human leukocyte antigen (HLA)-specific antibodies has been shown to be associated with graft loss and decreased patient survival, but it is not uncommon that donor-specific HLA antibodies are absent in patients with biopsy-proven antibody-mediated rejection. In this review, we focus on the latest findings on antibodies against non-HLA antigens in kidney and heart transplan...
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ژورنال
عنوان ژورنال: Chest
سال: 2013
ISSN: 0012-3692
DOI: 10.1378/chest.12-0587